WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:T cell receptor signaling pathway       ID:04660
C=108; O=12; E=0.24; R=50.98; rawP=1.30e-17; adjP=4.42e-16
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000153563 NA CD8A CD8a molecule 925 ENSG00000153563
2  ENSG00000163599 NA CTLA4 cytotoxic T-lymphocyte-associated protein 4 1493 ENSG00000163599
3  ENSG00000198286 NA CARD11 caspase recruitment domain family, member 11 84433 ENSG00000198286
4  ENSG00000182866 NA LCK lymphocyte-specific protein tyrosine kinase 3932 ENSG00000182866
5  ENSG00000115085 NA ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 7535 ENSG00000115085
6  ENSG00000198821 NA CD247 CD247 molecule 919 ENSG00000198821
7  ENSG00000198851 NA CD3E CD3e molecule, epsilon (CD3-TCR complex) 916 ENSG00000198851
8  ENSG00000160654 NA CD3G CD3g molecule, gamma (CD3-TCR complex) 917 ENSG00000160654
9  ENSG00000100351 NA GRAP2 GRB2-related adaptor protein 2 9402 ENSG00000100351
10  ENSG00000172116 NA CD8B CD8b molecule 926 ENSG00000172116
11  ENSG00000167286 NA CD3D CD3d molecule, delta (CD3-TCR complex) 915 ENSG00000167286
12  ENSG00000113263 NA ITK IL2-inducible T-cell kinase 3702 ENSG00000113263


Database:KEGG pathway       Name:Hematopoietic cell lineage       ID:04640
C=88; O=10; E=0.19; R=52.14; rawP=5.80e-15; adjP=9.54e-14
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000153563 NA CD8A CD8a molecule 925 ENSG00000153563
2  ENSG00000168685 NA IL7R interleukin 7 receptor 3575 ENSG00000168685
3  ENSG00000198851 NA CD3E CD3e molecule, epsilon (CD3-TCR complex) 916 ENSG00000198851
4  ENSG00000160654 NA CD3G CD3g molecule, gamma (CD3-TCR complex) 917 ENSG00000160654
5  ENSG00000172116 NA CD8B CD8b molecule 926 ENSG00000172116
6  ENSG00000167286 NA CD3D CD3d molecule, delta (CD3-TCR complex) 915 ENSG00000167286
7  ENSG00000173762 NA CD7 CD7 molecule 924 ENSG00000173762
8  ENSG00000116824 NA CD2 CD2 molecule 914 ENSG00000116824
9  ENSG00000156738 NA MS4A1 membrane-spanning 4-domains, subfamily A, member 1 931 ENSG00000156738
10  ENSG00000110448 NA CD5 CD5 molecule 921 ENSG00000110448


Database:KEGG pathway       Name:Primary immunodeficiency       ID:05340
C=35; O=8; E=0.08; R=104.87; rawP=8.42e-15; adjP=9.54e-14
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000153563 NA CD8A CD8a molecule 925 ENSG00000153563
2  ENSG00000168685 NA IL7R interleukin 7 receptor 3575 ENSG00000168685
3  ENSG00000182866 NA LCK lymphocyte-specific protein tyrosine kinase 3932 ENSG00000182866
4  ENSG00000115085 NA ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 7535 ENSG00000115085
5  ENSG00000198851 NA CD3E CD3e molecule, epsilon (CD3-TCR complex) 916 ENSG00000198851
6  ENSG00000147168 NA IL2RG interleukin 2 receptor, gamma 3561 ENSG00000147168
7  ENSG00000172116 NA CD8B CD8b molecule 926 ENSG00000172116
8  ENSG00000167286 NA CD3D CD3d molecule, delta (CD3-TCR complex) 915 ENSG00000167286


Database:KEGG pathway       Name:Cell adhesion molecules (CAMs)       ID:04514
C=133; O=10; E=0.29; R=34.50; rawP=4.00e-13; adjP=3.40e-12
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000234745 NA HLA-B major histocompatibility complex, class I, B 3106 ENSG00000234745
2  ENSG00000153563 NA CD8A CD8a molecule 925 ENSG00000153563
3  ENSG00000237541 NA HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3118 ENSG00000237541
4  ENSG00000139626 NA ITGB7 integrin, beta 7 3695 ENSG00000139626
5  ENSG00000005844 NA ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3683 ENSG00000005844
6  ENSG00000163599 NA CTLA4 cytotoxic T-lymphocyte-associated protein 4 1493 ENSG00000163599
7  ENSG00000013725 NA CD6 CD6 molecule 923 ENSG00000013725
8  ENSG00000172116 NA CD8B CD8b molecule 926 ENSG00000172116
9  ENSG00000166086 NA JAM3 junctional adhesion molecule 3 83700 ENSG00000166086
10  ENSG00000116824 NA CD2 CD2 molecule 914 ENSG00000116824


Database:KEGG pathway       Name:Natural killer cell mediated cytotoxicity       ID:04650
C=136; O=10; E=0.30; R=33.74; rawP=5.02e-13; adjP=3.41e-12
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000234745 NA HLA-B major histocompatibility complex, class I, B 3106 ENSG00000234745
2  ENSG00000005844 NA ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3683 ENSG00000005844
3  ENSG00000128340 NA RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 5880 ENSG00000128340
4  ENSG00000117091 NA CD48 CD48 molecule 962 ENSG00000117091
5  ENSG00000183918 NA SH2D1A SH2 domain containing 1A 4068 ENSG00000183918
6  ENSG00000182866 NA LCK lymphocyte-specific protein tyrosine kinase 3932 ENSG00000182866
7  ENSG00000115085 NA ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 7535 ENSG00000115085
8  ENSG00000198821 NA CD247 CD247 molecule 919 ENSG00000198821
9  ENSG00000100453 NA GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 3002 ENSG00000100453
10  ENSG00000180644 NA PRF1 perforin 1 (pore forming protein) 5551 ENSG00000180644


Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=9; E=0.58; R=15.58; rawP=7.35e-09; adjP=4.16e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000121966 NA CXCR4 chemokine (C-X-C motif) receptor 4 7852 ENSG00000121966
2  ENSG00000168685 NA IL7R interleukin 7 receptor 3575 ENSG00000168685
3  ENSG00000147168 NA IL2RG interleukin 2 receptor, gamma 3561 ENSG00000147168
4  ENSG00000129277 NA CCL4 chemokine (C-C motif) ligand 4 6351 ENSG00000129277
5  ENSG00000006075 NA CCL3 chemokine (C-C motif) ligand 3 6348 ENSG00000006075
6  ENSG00000161570 NA CCL5 chemokine (C-C motif) ligand 5 6352 ENSG00000161570
7  ENSG00000172215 NA CXCR6 chemokine (C-X-C motif) receptor 6 10663 ENSG00000172215
8  ENSG00000100385 NA IL2RB interleukin 2 receptor, beta 3560 ENSG00000100385
9  ENSG00000160791 NA CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1234 ENSG00000160791


Database:KEGG pathway       Name:Chemokine signaling pathway       ID:04062
C=189; O=8; E=0.41; R=19.42; rawP=9.46e-09; adjP=4.59e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128340 NA RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 5880 ENSG00000128340
2  ENSG00000121966 NA CXCR4 chemokine (C-X-C motif) receptor 4 7852 ENSG00000121966
3  ENSG00000129277 NA CCL4 chemokine (C-C motif) ligand 4 6351 ENSG00000129277
4  ENSG00000006075 NA CCL3 chemokine (C-C motif) ligand 3 6348 ENSG00000006075
5  ENSG00000161570 NA CCL5 chemokine (C-C motif) ligand 5 6352 ENSG00000161570
6  ENSG00000172215 NA CXCR6 chemokine (C-X-C motif) receptor 6 10663 ENSG00000172215
7  ENSG00000160791 NA CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1234 ENSG00000160791
8  ENSG00000113263 NA ITK IL2-inducible T-cell kinase 3702 ENSG00000113263


Database:KEGG pathway       Name:Autoimmune thyroid disease       ID:05320
C=52; O=5; E=0.11; R=44.12; rawP=1.06e-07; adjP=4.42e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000234745 NA HLA-B major histocompatibility complex, class I, B 3106 ENSG00000234745
2  ENSG00000237541 NA HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3118 ENSG00000237541
3  ENSG00000163599 NA CTLA4 cytotoxic T-lymphocyte-associated protein 4 1493 ENSG00000163599
4  ENSG00000180644 NA PRF1 perforin 1 (pore forming protein) 5551 ENSG00000180644
5  ENSG00000100453 NA GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 3002 ENSG00000100453


Database:KEGG pathway       Name:Chagas disease (American trypanosomiasis)       ID:05142
C=104; O=6; E=0.23; R=26.47; rawP=1.17e-07; adjP=4.42e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000167286 NA CD3D CD3d molecule, delta (CD3-TCR complex) 915 ENSG00000167286
2  ENSG00000006075 NA CCL3 chemokine (C-C motif) ligand 3 6348 ENSG00000006075
3  ENSG00000161570 NA CCL5 chemokine (C-C motif) ligand 5 6352 ENSG00000161570
4  ENSG00000198821 NA CD247 CD247 molecule 919 ENSG00000198821
5  ENSG00000198851 NA CD3E CD3e molecule, epsilon (CD3-TCR complex) 916 ENSG00000198851
6  ENSG00000160654 NA CD3G CD3g molecule, gamma (CD3-TCR complex) 917 ENSG00000160654


Database:KEGG pathway       Name:Leukocyte transendothelial migration       ID:04670
C=116; O=6; E=0.25; R=23.73; rawP=2.23e-07; adjP=7.58e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000005844 NA ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3683 ENSG00000005844
2  ENSG00000128340 NA RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 5880 ENSG00000128340
3  ENSG00000121966 NA CXCR4 chemokine (C-X-C motif) receptor 4 7852 ENSG00000121966
4  ENSG00000168421 NA RHOH ras homolog family member H 399 ENSG00000168421
5  ENSG00000166086 NA JAM3 junctional adhesion molecule 3 83700 ENSG00000166086
6  ENSG00000113263 NA ITK IL2-inducible T-cell kinase 3702 ENSG00000113263




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).